How Soft Is Secondary Electrospray Ionization?
Jérôme Kaeslin, Cedric Wüthrich, Stamatios Giannoukos, and Renato Zenobi
Secondary electrospray ionization (SESI) is a soft ionization method, which is important to avoid interference from in-source fragments and to simplify compound annotation. In this work, it is shown that SESI is softer than electrospray ionization (ESI), and therefore, SESI indeed qualifies as a soft ionization technique. However…
Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry
K.Dev Singh, G. Tancev, F. Decrue, J. Usemann, R. Appenzeller, P.Barreiro, G. Jaumà, M. Macia Santiago, G. Vidal de Miguel, U.Frey, P. Sinues
Despite the attractiveness of breath analysis as a non-invasive means to retrieve relevant metabolic information, its introduction into routine clinical practice remains a challenge.
Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization coupled to High Resolution Mass Spectrometry
Xue Li, Dan D. Huang, Rui Du, Zhi J. Zhang, Chak K. Chan, Zheng X. Huang, Zhen Zhou
Exhaled volatile organic compounds (VOCs) have aroused considerable interest, since they can serve as biomarkers for disease diagnosis and environmental exposure in a non-invasive manner. In this work, we present a protocol to characterize the exhaled VOCs in real time by using secondary nanoelectrospray ionization coupled to high resolution mass spectrometry (Sec-nanoESI-HRMS).
Translating secondary electrospray ionization–high-resolution mass spectrometry to the clinical environment
K. D. Singh, G. Vidal-de-Miguel, M. T.s Gaugg, A. J. Ibañez, R. Zenobi, M. Kohler, U. Frey and P. M-L Sinues
While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of how we think breath analysis will play a more prominent role …
Direct human breath analysis by secondary nano-electrospray ionization ultrahigh-resolution mass spectrometry: Importance of high mass resolution and mass accuracy
Xue Li, Lei Huang, Hui Zhu and Zhen Zhou.
RATIONALE: Direct mass spectrometry (MS)-based methods make it possible to monitor the molecular compositions of hundreds of volatile organic compounds (VOCs) in exhaled human breath in real time. Mass resolution and mass accuracy play important roles for direct MS analysis, especially for the low-concentration isobaric compounds in non-target research.
Noninvasive strategies for breast cancer early detection
G. Trecate, P. M-L Sinues & R. Orlandi
Breast cancer screening and presurgical diagnosis are currently based on mammography, ultrasound and more sensitive imaging technologies; however, noninvasive biomarkers represent both a challenge and an opportunity for early detection of cancer …
Real-Time Chemical Analysis of E-Cigarette Aerosols by Means of Secondary Electrospray Ionization Mass Spectrometry
D. Garcia-Gomez, T. Gaisl, C. Barrios-Collado, Guillermo Vidal-de-Miguel, M. Kohler and R. Zenobi
Chemical analysis of aerosols collected from electronic cigarettes (ECs) has shown that these devices produce vapors that contain harmful and potentially harmful compounds. Conventional analytical methods used for the analysis of electronic cigarettes do not reflect the actual composition of the aerosols generated because they usually neglect the changes in the chemical composition that occur during the aerosol generation process and after collection.
Numerical modeling and experimental validation of a universal secondary electrospray ionization source for mass spectrometric gas analysis in real-time
C. Barrios-Collado, G. Vidal-de-Miguel, P. M-L Sinues
The process by which ambient vapors are ionized upon interaction with electrosprays is not fully under-stood, compromising its optimization and widespread use. In this work we evaluated the different scales associated with the processes involved in secondary electrospray ionization (SESI) and developed a new numerical method …