Sarah Basler, Noriane A Sievi, Felix Schmidt, Kai Fricke, Alexandra Arvaji, Jonas Herth, Diego M Baur, Pablo Sinues, Silvia Ulrich and Malcolm Kohler

Metabolic changes in the linoleate, tyrosine, and tryptophan pathways during AECOPD were predominant. Significant metabolic changes occur during COPD exacerbations, predominantly in the linoleate, tyrosine, and tryptophan pathways, which are all linked to inflammation. Real-time exhaled breath analysis enables a good prediction of AECOPD compared to stable state and thus could enhance precision of AECOPD diagnosis and efficacy in clinical practice.

Wolfram Miekisch, Pritam Sukul, Jochen K. Schubert

As dynamic VOC profiling provides valuable information on kinetics of markers and confounders, it offers huge and so far unexplored potential for physiological, metabolic, therapeutic and environmental monitoring. Driven by new and innovative technologies such as real time mass spectrometry and highly specific sensor systems, future applications may range from home care to ICU monitoring

Siyu Liu, Jinli Xu, Yingxin Xie, Bowen He, Qingxin Deng, Yanan Hu, Jiangping Liu, Davide Vione, Xue Li, Sasho Gligorovski

Real-time measurements of the gas-phase product compounds formed by the reaction of O₃ with BDE-209 were performed with a SESI-HRMS in both positive and negative ionization modes…

Chen Tao, Peter Mettke, Yaru Wang, Xue Li, Ligang Hu

Highlights

• Near-surface ozone pollution has a significant impact on respiratory health.

• Lung microenvironment is involved in respiratory health effects of ozone pollution.

• Exhalation metabolomics provides a new method to explore the respiratory health effects of ozone pollution.

• Exhalation metabolomics could be a potential basis for concentration limits in ozone pollution control.

Wei Liu, Li Zhou, Wenting Yuan, Ling Ruan, Xinkai Wang, Yucong Guo, Zhouqing Xie, Qifan Liu, Chen Wang

This review article summarizes the principles of different online mass spectrometry techniques and their application to indoor VOC measurements. The sources, emission characteristics, and chemical compositions of primary indoor VOCs are discussed. Recent advances in the fundamental understanding of chemical transformations and formation mechanisms related to secondary indoor VOCs are also discussed

Xin Xu, Hongwei Pang, Chao Liu, Kangyi Wang, Gwendal Loisel, Lei Li, Sasho Gligorovski, Xue Li

Human presence can affect indoor air quality because of secondary organic compounds formed upon reactions between gaseous oxidant species, e.g., ozone (O₃), hydroxyl radicals (OH), and chemical compounds from skin, exhaled breath, hair and clothes. We assess the gas-phase product compounds generated by reactions of gaseous O₃ with volatile organic compounds (VOCs) from exhaled human breath…

Huifan Deng, Xin Xu, Kangyi Wang, Jinli Xu, Gwendal Loisel, Yiqun Wang, Hongwei Pang, Pan Li, Zebin Mai, Shichao Yan, Xue Li,Sasho Gligorovski

The primarily emitted compounds by human presence, e.g., skin and volatile organic compounds (VOCs) in breath, can react with typical indoor air oxidants, ozone (O₃), and hydroxyl radicals (OH), leading to secondary organic compounds…

Huifan Deng, Pascale S. J. Lakey, Yiqun Wang, Pan Li, Jinli Xu, Hongwei Pang, Jiangping Liu, Xin Xu, Xue Li, Xinming Wang, Yuzhong Zhang, Manabu Shiraiwa, and Sasho Gligorovski

The reactions of sulfur dioxide (SO₂) with surface-bound compounds on atmospheric aerosols lead to the formation of organic sulfur (OS) compounds, thereby affecting the air quality and climate. Here, we show that the heterogeneous reaction of SO₂ with authentic urban grime under near-ultraviolet sunlight irradiation leads to a large suite of various organic compounds including OS released in the gas phase…

Yiqun Wang, Huifan Deng, Pan Li, Jinli Xu, Gwendal Loisel, Hongwei Pang, Xin Xu, Xue Li, Sasho Gligorovski

Little is known about the processes of formation of the secondarily formed N-containing organics in the atmosphere. Here, we investigated the formation of gas-phase organic compounds, including N-containing organics, through interfacial oxidation chemistry of gaseous O₃ with an authentic riverine surface microlayer (SML) by using a high-resolution quadrupole Orbitrap mass spectrometer coupled to a secondary electrospray ionization source…

Jiafa Zeng, Majda Mekic, Xin Xu, Gwendal Loisel, Zhen Zhou, Sasho Gligorovski, Xue Li

we evaluate the secondary organic compounds formed through heterogeneous reactions of gaseous O₃ with hand skin lipids by using a high-resolution quadrupole Orbitrap mass spectrometer coupled to a commercial secondary electrospray ionization (SESI) source… we suggest detailed reaction pathways initiated by ozone oxidation of squalene that results in primary and secondary ozonides…

Majda Mekic, Jiafa Zeng, Bin Jiang, Xue Li, Yannis G. Lazarou, Marcello Brigante, Hartmut Herrmann, Sasho Gligorovski

When aqueous solutions containing a mixture of fluorene (FL) and DMSO are irradiated with actinic radiation, a large suite of unsaturated high molecular weight compounds appear in the aqueous phase; a broad variety of saturated and unsaturated oxygenated multifunctional compounds are also observed in the gas phase, most of which are more toxic than FL

J-C Wolf, M. Schaer, P. Siegenthaler, R. Zenobi

A novel active capillary dielectric barrier discharge plasma ionization (DBDI) technique for mass spectrometry is applied to the direct detection of thirteen chemical warfare related compounds, including sarin, and compared to secondary electrospray ionization (SESI) in terms of selectivity and sensitivity.