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Breath response following a nutritional challenge monitored by secondary electrospray ionization high-resolution mass spectrometry

C. Wüthrich, M.de Figueiredo, K. J. Burton-Pimentel, G. Vergères, F. Wahl, R. Zenobi and S. Giannoukos

For the first time, this study demonstrates the application of SESI-HRMS in the field of nutritional science using a standardized nutritional intervention, consisting of a high-energy shake. Tentative compounds include fatty acids, amino acids, and amino acid derivatives, some of them likely derived from nutrients by the gut microbiome, as well as organic acids from the Krebs cycle. Time-series clustering showed an overlap of observed kinetic trends with those reported previously in blood plasma.

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Seeing the smell of garlic: Detection of gas phase volatiles from crushedgarlic (Allium sativum), onion (Allium cepa), ramsons (Allium ursinum) andhuman garlic breath using SESI-Orbitrap MS

Hendrik G. Mengers, Christina Schier, Martin Zimmermann, Martin C. H. Gruhlke, Eric Block, Lars M. Blank*, Alan J. Slusarenko

Using SESI-Orbitrap MS, we measured gas phase concentrations of allicin evaporating from a pure solution. The SESI-Orbitrap MS was used to follow the known chemistry of alliin, isoallin and methiin conversion in garlic, onion and ramsons. Allicin and its metabolites were also measured in human breath after garlic consumption. These results demonstrate the utility of SESI-Orbitrap MS for analysis of sulfur-containing volatiles from plants and for capturing volatilomes of foodstuffs in general.

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Food Guillermo Vidal Food Guillermo Vidal

Evolution of indoor cooking emissions captured by using secondary electrospray ionization high resolution mass spectrometry

Jiafa Zeng, Zhujun Yu, Majda Mekic, Jiangping Liu, Sheng Li, Gwendal Loisel, Wei Gao, Adrien Gandolfo, Zhen Zhou, Xinming Wang, Hartmut Herrmann, Sasho Gligorovski, and Xue Li.

Cooking emissions represent a major source of air pollution in the indoor environment and exhibit adverse health effects caused by particulate matter together with volatile organic compounds (VOCs).

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Guillermo Vidal Guillermo Vidal

Rapid fingerprinting of grape volatile composition using SESI orbitrap MS: A preliminary study of grape ripening

R. R. Farrell, J. Fahrentrapp, D. Garcia Gomez, P. M-L Sinues, and R. Zenobi

Even though sugar and acidity measurements are the most common indices of grape maturity, it is well recognized that they provide only basic information related to wine quality. In this preliminary study te authors use SESI-MS to analyze VOCs directly from intact grapes without sample concentration.

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Microbiology Guillermo Vidal Microbiology Guillermo Vidal

Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization – mass spectrometry

L. Bregy, A. R. Müggler, P. M-L Sinues, D. García-Gómez, Y. Suter, G. N. Belibasakis, M. Kohler, P. R. Schmidlin, Renato Zenobi

The detection of bacterial-specific volatile metabolites may be a valuable tool to predict infection. Here we applied a real-time mass spectrometric technique to investigate differences in volatile metabolic profiles of oral bacteria that cause periodontitis. We coupled a secondary electrospray ionization (SESI) source to a commercial high-resolution mass spectrometer …

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Guillermo Vidal Guillermo Vidal

Profiling Aged Artisanal Cheddar Cheese Using Secondary Electrospray Ionization-Mass Spectrometry (SESI-MS)

H. D. Bean, T. R. Mellors, J. Zhu and J. E. Hill

A number of direct injection mass spectrometry methods that can sample foods nondestructively and without sample preparation are being developed with applications ranging from the rapid assessment of food safety to the verification of protected designations of origin. In this pilot study, SESI-MS in positive and negative-ion modes was used to …

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Guillermo Vidal Guillermo Vidal

In situ detection of hydroxybutyrate and butyrolactone in drinks by secondary electrospray ionization

Christian Berchtold; Stefan Schmid; Lukas Meiera and Renato Zenobi.

γ-Hydroxybutyrate (GHB) and γ-butyrolactone (GBL) are used as “date rape drugs” since they cause catalepsy and memory loss. A new application of secondary electrospray ionization (SESI) mass spectrometry for in situ detection of GHB and GBL in drinks and body fluids is introduced.

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Guillermo Vidal Guillermo Vidal

Simultaneous sampling of volatile and non-volatile analytes in beer for fast fingerprinting by extractive electrospray ionization mass spectrometry

Liang Zhu, Zhong Hu, G. Gamez, Wai Siang Law, Huan Wen Chen, ShuiPing Yang, Konstantin Chingin, Roman M. Balabin, Rui Wang, TingTing Zhang, R. Zenobi

By gently bubbling nitrogen gas through beer, an effervescent beverage, both volatile and non-volatile compounds can be simultaneously sampled in the form of aerosol. This allows for fast (within seconds) fingerprinting by extractive electrospray ionization mass spectrometry (EESI-MS) in both negative and positive ion mode, without the need for any sample pre-treatment …

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Guillermo Vidal Guillermo Vidal

Sampling analytes from cheese products for fast detection using neutral desorption extractive electrospray ionization mass spectrometry

Zhongchen Wu, Konstantin Chingin, Huanwen Chen, Liang Zhu, Bin Jia, R. Zenobi

The development of analytical techniques suitable for sensitive, high-throughput, and nondestructive food analysis has been of increasing interest in recent years. In this study, mass-spectral fingerprints of various cheese products were rapidly recorded in the mass range of m/z 50-300 Da without any sample pretreatment, using ND-EESI-MS in negative ion mode.

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