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Early detection of bacterial pneumonia by characteristic induced odor signatures

Kim Arnold, Alejandro Gómez-Mejia, Miguel de Figueiredo, Julien Boccard, Kapil Dev Singh, Serge Rudaz, Pablo Sinues & Annelies S. Zinkernagel


This study refines the application of the non-invasive Secondary Electrospray Ionization-High Resolution Mass Spectrometry (SESI-HRMS) methodology for real-time and early detection of human respiratory bacterial pathogens in the respiratory tract of a mouse infection model

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In vivo detection of metabolic 2H-incorporation upon ingestion of 2H2O

Kim Arnold, Xing Chen, Hui Zhang, Kapil Dev Singh, Zhihong Yin, Yao Yao, Tiangang Luan, Pablo Sinues, and Xue Li

Secondary electrospray ionization-high resolution mass spectrometry allows monitoring in vivo 2H-incorporation of metabolites in a non-invasive and real-time setup and opens new opportunities to use 2H tracing to extend current metabolic studies, especially those with a focus on anaerobic glycolysis, lysine methylation and gut microbiome via monitoring of short-chain fatty acids.

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