Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry
H. Chen, A. Wortmann, W. Zhang, and R. Zenobi
Quantitative analysis of trace constituents in exhaled gas can provide useful insights into biochemical processes in the body, thus revealing information about metabolic dynamics and providing, theoretically, a scientific base for biomarker research or clinical diagnoses. Breath, however, is rarely used practically for diagnostic purposes in clinical medicine …
Secondary Electrospray Ionization-Ion Mobility Spectrometry for Explosive Vapor Detection
M. Tam and H. H. Hill, Jr.
The unique capability of secondary electrospray ionization (SESI) as a nonradioactive ionization source to detect analytes in both liquid and gaseous samples was evaluated using aqueous solutions of three common military explosives: cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX), nitroglycerin (NG) and pentaerythritol tetranitrate (PETN).
Secondary Ionization of Chemical Warfare Agent Simulants: Atmospheric Pressure Ion Mobility Time-of-Flight Mass Spectrometry
W. E. Steiner, B. H. Clowers, P. E. Haigh, and H. H. Hill
For the first time, the use of a traditional ionization source for ion mobility spectrometry (radioactive nickel (63Ni) beta emission ionization) and three alternative ionization sources (electrospray ionization (ESI), secondary electrospray ionization (SESI), and electrical discharge (corona) ionization (CI)) were employed with …
Secondary Electrospray Ionization Ion Mobility Spectrometry/Mass Spectrometry of Illicit Drugs
C. Wu, W. F. Siems, and H. H. Hill, Jr.
A secondary electrospray ionization (SESI) method was developed as a nonradioactive ionization source for ion mobility spectrometry (IMS). This SESI method relied on the gas-phase interaction between charged particles created by electrospray ionization (ESI) and neutral gaseous sample molecules. Mass spectrometry (MS) was used as …