Blog
Screening of highly relevant compounds in the inhaled route
Secondary electrospray ionization and tools like Super SESI allow us to safely detect large molecules in the gas phase, with an extremely low LoD.
This is what the offline solution for Super SESI looks like
We have developed this first pilot unit within the PERFECT LIFE project (funded by the European Union). It comprises a gas conditioning unit, a desorber, the Super SESI, the MS, and of course, the cartridges!
The relevant role of humidity in Secondary Electrospray Ionization (SESI)
Rising the humidity level of the gas introduced through the sample line accelerates the charge transfer reaction rate in Secondary Electrospray Ionization (SESI). It is hypothesized that larger clusters transfer their charge more efficiently than smaller clusters or even bare ions.
THE DIFFICULTY OF DETECTING LOW VOLATILITY SPECIES FOR VOC ANALYSIS TECHNOLOGIES
As you probably already know, current VOC MS analyzers can detect high volatile species, even when they are present in very low concentrations. For instance, in 2009 P. Spanel and D. Smith measured the concentration of ammonia, acetone, methanol, ethanol, and isoprene in human breath using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) [1] .
Differences between SESI and APCI ambient ionization techniques
In the equilibrium, both Secondary Electro Spray Ionization (SESI) and Atmospheric Pressure Chemical Ionization (APCI) generate charged water clusters that act as charging agents. What are the differences bewtween these ionization techniques?
How Secondary Electro-Spray Ionization (SESI) works
Secondary Electro-Spray Ionization (SESI) uses a nano-electrospray that produces a cloud of charging ions. These ions ionize the vapor molecules that are in contact with the cloud.