Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath

Gerardo Gamez, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Gunter Kramerb and Renato Zenobi.

Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breathw.jpg

Abstract: Valproic acid pharmacokinetics and ingestion in humans can be monitored through a novel biomarker in exhaled breath. The EESI-MS technique is direct and simple, noninvasive, pain free, and represents an important step toward individualized drug therapy.

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Characterizing Bacterial Volatiles using Secondary Electrospray Ionization Mass Spectrometry (SESI-MS)

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Secondary electrospray ionization-mass spectrometry: breath study on a control group