Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath
Gerardo Gamez, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Gunter Kramerb and Renato Zenobi.
Abstract: Valproic acid pharmacokinetics and ingestion in humans can be monitored through a novel biomarker in exhaled breath. The EESI-MS technique is direct and simple, noninvasive, pain free, and represents an important step toward individualized drug therapy.