Monitoring of Exogenous Compound Kinetics in Exhaled Breath
Happy holidays! Christmas is here: Social life, family, parties, more eating, drinking... and smoking.
We all know smoking is harmful. But a lot remains yet to know about how exactly it harms. The pharmacokinetics of inhaled substances remains partly a mystery. But thanks to SuperSESI we can finally see, accurately and in real time, what happens in our lungs after smoking.
Real-time breath analysis is an advantageous analytical approach by which information about physiological changes over a short period of time can be obtained.
Real-time analysis of human exhaled breath enables rapid monitoring of exposure-driven absorption of exogenous volatile organic compounds (VOC) from the lungs into the bloodstream.
In a study by Philip Morris International and FIT, Exhalion Super SESI coupled to a Q-Exactive HF mass spectrometry system allowed rapid detection, confirmation and monitoring of the absorption of exogenous compounds originating from cigarette smoke and other inhalable products from the lungs into the bloodstream.
The pharmacokinetics of nicotine, indole (an endogenous metabolite, camphor, and pyridoxal —which were confirmed in a tested inhalable product— were profiled.
These results demonstrate the benefits of Super SESI in studying real-time exhaled breath samples.
This study was possible thanks to T. Zivkovic Semren, C. Laszlo 1, M. Gomez, G. Vidal-de-Miguel, J. Hoeng 1, M. Peitsch, N. Ivanov, P.A. Guy.
