Demo: a SUPER SESI-Orbitrap system will be installed at the SUMS laboratory to show breath analysis in real-time and other samples.

Seminario en la Facultad de Farmacia de Albacete (UCLM): Análisis del volatiloma en tiempo real - Avances técnicos e instrumentales

PMI has decided to bet on a smoke-free future. For this, they have decided to make the required investments in biomedical research and scientific equipment. The goal is to replace cigarettes as soon as possible with smoke-free alternatives.SUPER SESI will help to asses the kinetics of different smoke-free products, and lower the risk of harm caused by smoking.

In the last ten years, we have developed the tools required to analyze dynamic changes in metabolism. A key technical challenge was to detect large and biologically relevant molecules in the gas phase, which allowed for the analysis of respiration metabolites. This article describes and illustrates this new window into the metabolism and the volatilome. With an exclusive look at high ionization efficiency of Secondary Electro-Spray Ionization (SESI) and Super SESI application.

Post-doctoral researcher Kapil Dev Singh (UKBB) presented part of his studies on therapeutic drug monitoring at the MSACL congress. They measured exhaled breath in pediatric patients treated with antiepileptic medication, and compared it with Gold Standard blood test. They identified secondary metabolites of valproic acid (VPA), and were able to predict the serum concentration of total and free VPA in real time in a non-invasive way, using the platform SUPER SESI - Orbitrap.

We just installed a second Super SESI at the National Cancer Research Institute of Italy to initiate the first multicenter study based on this technology to diagnose neck cancer with breath analysis.

Due to its proximity to the upper airways, breath analysis is an ideal non-invasive diagnostic approach to detect this disease at an early stage. We are committed to serving scientists and proud to contribute to the improvement of the health of so many people.

First day at the Breath Summit (Loughborough, UK)! Honored for sharing this time with the Breath Research community. Do not miss Guillermo Vidal's talk on Monday at 16:35h. He will talk about Real-time breath analysis with SESI-HRMS and standardization.

Prof. Jiangjiang Zhu and colleagues develop metabolomics techniques based on Super SESI-Orbitrap to study lung and colorectal cancer, intestinal bacteria and their influence on cancer.

We have recently installed a new Super SESI and a new Exhalion, that will work in tandem with a Thermo QExactive Plus. This investment validates the technology.

With this acquisition, ETH Zurich (Switzerland) consolidates its position as a top research institution, leading the field of breath research.

Presentation of our Corporate poster on detecting low volatility metabolites in the gas phase to resolve the time dimension of your metabolomic studies at ASMS Atlanta 2019.

Presentation of our Scietific poster on Real-time Breath analysis confounding variables and standardization strategies at ASMS-Atlanta 2019.

If you are working in metabolomics, pharmacokinetics, biomarker identification, VOC analysis, or other related topic, we would like to invite you to our booth and discuss about how we can help or cooperate with you.

University Hospital of Zurich use Super SESI QExactive Plus installed by Fossil Ion Technology and Thermo Fisher Scientific.

We are proud that Jinan University is now using SUPER SESI for breath analysis and environmental analysis.

We hope this new Super SESI Exhalion coupled with the Orbitrap Mass Spectrometer Q Exactive, will allow the IMSAE researchers to focus on their scientific findings, while taking consistency and performance for granted.

SESI and ESI (Electro-Spary Ionization) have been linked since the initial development of ESI. Fenn and colleagues already noted that gas-phase species in the counterflow gas were also ionized by the spray. Still today, the routine calibration of mass spectral data relies on ubiquitous plasticizes and other contaminants (i.e. polydimethylcyclosiloxanes, phthalates) that are ionized in regular ESI via Secondary Electrospray Ionization mechanisms.

The ETH Zurich (Switzerland) has recently completed the acquisition and installation process of a new SUPER SESI unit for a Thermo Fisher Scientific Orbitrap mass spectrometer, that will help in different fields of the research conducted at this institution related to metabolomic studies.

Rising the humidity level of the gas introduced through the sample line accelerates the charge transfer reaction rate in Secondary Electrospray Ionization (SESI). It is hypothesized that larger clusters transfer their charge more efficiently than smaller clusters or even bare ions.

As you probably already know, current VOC MS analyzers can detect high volatile species, even when they are present in very low concentrations. For instance, in 2009 P. Spanel and D. Smith measured the concentration of ammonia, acetone, methanol, ethanol, and isoprene in human breath using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) [1] .

In the equilibrium, both Secondary Electro Spray Ionization (SESI) and Atmospheric Pressure Chemical Ionization (APCI) generate charged water clusters that act as charging agents. What are the differences bewtween these ionization techniques?

The European Organization for Nuclear Research (CERN) has officially reached an agreement with Fossiliontech through a project supported by Ineustar-Pioneers and Promalaga to develop a data processing system tool incorporating CERN algorithms, in order to create a post-processing server that shares the conclusions obtained by all scientists working on breath analysis with SUPER SESI.