Advances in secondary electrospray ionization for breath analysis and volatilomics

Written By Jamil Khirbek

Cedric Wüthrich, Stamatios Giannoukos

Abstract

The measurement of volatile organic compounds (VOCs) originating from organisms allows continuous monitoring and a unique insight into the metabolism. One method offering the sensitivity to detect these VOCs is secondary electrospray ionization coupled to high-resolution mass spectrometry (SESI-HRMS). SESI was derived from electrospray ionization (ESI) and has found widespread application in clinical research and monitoring of animals. This review discusses the technical aspects behind SESI, the advancements, and the technical hurdles faced. Additionally, the recent advances in the applications of SESI in human and animal-centered research are presented.

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Jamil Khirbek
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Data Collection of" Alternative Electrolyte Solutions for Untargeted Breath Metabolomics with Secondary-Electrospray Ionization High-Resolution Mass Spectrometry"
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Preservation of exhaled breath samples for analysis by off-line SESI-HRMS: proof-of-concept study